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KMID : 0376219810180020207
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Chonnam Medical Journal
1981 Volume.18 No. 2 p.207 ~ p.213
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Bactericidal Activity of the Mixture of Streptomycin and Bacteriophage
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Abstract
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The author investigated, by using the Klebsiella phage-host cell system, the bactericidal activity of the mixture of streptomycin(SM) and bacteriophage (phage). The following results were obtained.
The bactericidal activity of SM plus phage was stronger than that of SM or phage alone.
The bacteria cultured for 3 hours under aeration were a little more killed by SM plus. phage than that cultured overnight.
Under the condition of similar cell number, more phage dose than a level was necessary for expecting the stronger bactericidal activity of SM plus phage than that of SM alone.
At 21st hour of reaction time, the viable bacteria in the SM plus phage-tube and SM alone-tube were similarly decreased and, at 30th hour, the viable bacteria in both tubes were again increased. However, the increasing grade in SM plus -phage-tube was lower than that in SM alone-tube and, the more the phage was added, the more inhibited the increasing of viable bacteria.
The SM did not give any special influence to the phage itself.
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KEYWORD
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